Synthesis and characterization of a synthetic heme-based oxygen carrier

✍ Scribed by Loola Al-Kassim; Z Wang; Arthur G Szabo; Keith E Taylor; Bulent Mutus

• Book ID: 102314977
• Publisher: Wiley (John Wiley & Sons)
• Year: 2005
• Tongue: English
• Weight: 122 KB
• Volume: 80
• Category: Article
• ISSN: 0268-2575
• DOI: 10.1002/jctb.1279

✦ Synopsis

Abstract

We have prepared a novel oxygen carrier composed of Starburst dendrimer 3 hematoporphyrin iron(III) di‐1‐(3‐aminopropyl)imidazole di‐succinic acid (SDHAPI). This compound has a molecular weight of ∼12.7 kD. O~2~ and CO binding to SDHAPI was demonstrated by UV‐vis spectroscopy. Oxygenated SDHAPI had an estimated auto‐oxidation half‐life of 24 min. The oxygen stoichiometry (∼6 mol of O~2~ mol^−1^ SDHAPI) and the k~obs(on+off)~ of 0.084 s^−1^ and k~obs(off)~ of 0.009 s^−1^ were estimated with an oxygen electrode. Copyright © 2005 Society of Chemical Industry