Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling

Synthesis and characterization of a sulf

Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling

✍ Stefania De Luca; Giancarlo Morelli 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract Two cyclic peptides, cyclo^29, 34^[Dpr^29^, Lys^34^(DTPA‐Glu)]‐CCK8 (**1**) and cyclo^29, 34^[Tyr^27^(SO~3~H), Dpr^29^, Lys^34^(DTPA‐Glu)]‐CCK8 (**2**), bearing the chelating moiety DTPA‐Glu covalently bound to the Lys side chain have been synthesized by solid‐phase methodology. The pre