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Synthesis and Characterization of a New 5-Thiol-Protected Deoxyuridine Phosphoramidite for Site-Specific Modification of DNA †

✍ Scribed by Meyer, Karen L.; Hanna, Michelle M.


Book ID
118221090
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
344 KB
Volume
7
Category
Article
ISSN
1043-1802

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Synthesis of 5-(2-Pyrenyl)-2′-deoxyuridi
✍ Claudia Wanninger-Weiß; Hans-Achim Wagenknecht 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

## Abstract 5‐(2‐Pyrenyl)‐2′‐deoxyuridine (2PydU, **2**) has been prepared as a new thymidine analogue in which the 2‐position of the pyrene chromophore is connected covalently to the 5‐position of uridine through a single C–C bond. The synthesis of **2** starts with the conversion of pyrene (**3**