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Synthesis and Characterization of a Cobalamin−Colchicine Conjugate as a Novel Tumor-Targeted Cytotoxin

✍ Scribed by Bagnato, Joshua D.; Eilers, Alanna L.; Horton, Robert A.; Grissom, Charles B.

Book ID
111928857
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
177 KB
Volume
69
Category
Article
ISSN
0022-3263

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## Abstract The synthesis of the novel pentagastrin seco‐CBI conjugate **3**, which is based on the highly cytotoxic antitumor antibiotic (+)‐duocarmycin SA (**1**), is reported. A key step in the synthesis is the palladium‐catalyzed carbonylation of aryl bromide **7** to give the benzyl ester **16