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Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones

โœ Scribed by Bandurco, Victor T.; Schwender, Charles F.; Bell, Stanley C.; Combs, Donald W.; Kanojia, Ramesh M.; Levine, Seymour D.; Mulvey, Dennis M.; Appollina, Mary A.; Reed, Marianne S.


Book ID
111985260
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
778 KB
Volume
30
Category
Article
ISSN
0022-2623

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An efficient synthesis of 4-alkyl-2(1H)-
โœ Honggen Wang; Lanying Liu; Yong Wang; Changlan Peng; Jiancun Zhang; Qiang Zhu ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 270 KB

An efficient synthesis of 4-alkyl-2(1H)-quinazolinones has been achieved by cyclization of 1-(2-alkynylphenyl)ureas (2 R 2 = alkyl) in dichloroethane catalyzed by TfOH. In the case of aryl substitution (2 R 2 = aryl), a mixture of quinazolinone tautomers is obtained in dichloroethane with TFA as co-