Synthesis and Bladder Smooth Muscle Relaxing Properties of Substituted 3-Amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones.
โ Scribed by John A. Butera; Douglas J. Jenkins; Joseph R. Lennox; Jeffrey H. Sheldon; N. Wesley Norton; Dawn Warga; Thomas M. Argentieri
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 14 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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Cyclization of 2- (N-acetyl-N-arylamino)nicotinonitriles in the presence of dry HCI gave 1-aryl-2-methyl-4-oxo-l,4-dihydropyrido[2,3-d]pyrimidines. It was shown that they are acylated by acetic anhydride, aroyl chlorides, and phenyl isocyanate at the methyl group and that with benzaldehyde they give