Synthesis and Biology of a 7-Nitro-2,1,3-benzoxadiazol-4-yl Derivative of 2-Phenylindole-3-acetamide: A Fluorescent Probe for the Peripheral-Type Benzodiazepine Receptor
✍ Scribed by Kozikowski, Alan P.; Kotoula, Maria; Ma, Dawei; Boujrad, Noureddine; Tückmantel, Werner; Papadopoulos, Vassilios
- Book ID
- 115440627
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 157 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Recently, a new 2‐(iodophenyl)imidazo[1,2‐__a__]pyridineacetamide series has been developed as iodine‐123‐labelled radioligands for imaging the peripheral benzodiazepine receptors using single photon emission tomography. Within this series, 2‐[6‐chloro‐2‐(4‐iodophenyl)‐imidazo[1,2‐__a__
3 H]-Labelled 4- [ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[ 3 H]-butan-1-ol (3b) was prepared as a novel non-peptidic radiolabelled high affinity antagonist of the corticotropin-releasing hormone type 1 receptor (CRHR 1 ) that could be useful as a more