𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biological study of some new chalcones and oxopyrimidines containing imidazo[1,2-a]pyridine nucleus

✍ Scribed by M. J. Joshi; P. B. Vekariya; B. L. Dodiya; R. M. Ghetiya; H. S. Joshi

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
126 KB
Volume
49
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Heterosubstituted chalcones and oxopyrimidines were synthesized by the reaction of 2‐(4‐Chlorophenyl)imidazo[1,2‐a]pyridine‐3‐carbaldehyde 1 and different aryl acetophenone in the presence of catalytic amount of 40% alkali to give (2__E__)‐3‐(2‐(4‐chlorophenyl)imidazo[1,2‐a]pyridin‐3‐yl)‐1‐arylprop‐2‐en‐1‐ones 2a–l. Compounds 2a–l on reaction with urea in the presence of basic catalyst such as KOH to give 6‐(2‐(4‐chlorophenyl)imidazo[1,2‐a]pyridin‐3‐yl)‐4‐aryl pyrimidin‐2(1__H__)‐ones 3a–l. Their IR, ^1^H‐NMR, MASS spectral data, and elemental analysis were in accord with assigned structure. All the newly synthesized compounds were screened for their antimicrobial activity. J. Heterocyclic Chem., (2012).

📜 SIMILAR VOLUMES

ChemInform Abstract: Reactions with Hydr
ChemInform Abstract: Reactions with Hydrazonoyl Halides. Part 62. Synthesis and Antimicrobial Evaluation of Some New Imidazo[1,2-a]pyrimidine, Imidazo[1,2-a]pyridine, Imidazo[1,2-b]pyrazole, and Quinoxaline Derivatives.
✍ Abdou O. Abdelhamid; Eman K. A. Abdelall; Yasser H. Zaki 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 22 KB 👁 2 views

## Abstract A series of novel heterocyclic compounds is synthesized using hydrazonoyl bromide (I) as starting compound.

Reactions with hydrazonoyl halides 62: S
Reactions with hydrazonoyl halides 62: Synthesis and antimicrobial evaluation of some new imidazo[1,2-a]pyrimidine, imidazo [1,2-a]pyridine, imdazo[1,2-b]pyrazole, and quinoxaline derivatives
✍ Abdou O. Abdelhamid; Eman K. A. Abdelall; Yasser H. Zaki 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 133 KB 👁 1 views

## Abstract magnified image 3‐Arylazo‐2‐(4‐methyl‐2‐phenylthiazol‐5‐yl)imidazo[1,2‐__a__]pyrimidine, 2‐(4‐methyl‐2‐phenyl‐1,3‐thiazol‐5‐yl)‐3‐phenylazoimidazo[1,2‐__a__]pyridine, 3‐arylazo‐2‐(4‐methyl‐2‐phenylthiazol‐5‐yl)‐6‐phenyl‐5__H__‐imidazo[1,2‐__b__]pyrazole, 6‐(4‐methyl‐2‐phenyl‐thiazol‐5‐y