Synthesis and biological study of a new series of bifunctional organoiron thio- and seleno-terephthalate derivatives (C5H5)Fe(CO)2ECO(C6H4)COX (E = S, X = R2N, RNH, NH2, OH, Cl; E = Se, X = RNH, RS, RCOO, NH2, OH, Cl)
✍ Scribed by Ahmed O. Maslat; Ibrahim Jibril; Mahmoud Abussaud; Emad H. Abd-Alhadi; Zuhair Hamadah
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 154 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0268-2605
- DOI
- 10.1002/aoc.257
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✦ Synopsis
H 5 ÐC 2 N 2 OÐS, mÐNO 2 ÐC 6 H 4 ÐCH=CHÐCOO] Ð has been synthesized via the organic transformation reactions of the terephthaloyl chloride precursors Z-(C 5 H 5 )Fe(CO) 2 ECO(C 6 H 4 )COCl with the desired nucleophiles. These new complexes were characterized by elemental analysis, IR and 1 H NMR spectra. The above complexes, in addition to some other selected analogues, were tested for their antifungal, antibacterial and mutagenic activity. Our results show that all the seleniumcontaining compounds have antifungal activity on Candida albicans and antibacterial effects against Bacillus subtilis and Staphylococcus aureus. Four of the six selenium-containing derivatives exhibited growth inhibitory effects against Pseudomonas aeruginosa and/or Escherichia coli. Sulfurcontaining derivatives elicited activity against C. albicans, and each one of them showed activity against at least one of the bacterial strains that have been used in this investigation. Two seleniumand two sulfur-containing derivatives showed mutagenic activity against one or more than one strain of the Salmonella typhimurium using the Ames test.