Synthesis and biological study of 6-polyhydroxyalkylpteridines

✍ Scribed by M. Dolores López; M. Luisa Quijano; Adolfo Sánchez; Manuel Nogueras; John N. Low

• Book ID: 102345186
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 132 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380331

✦ Synopsis

Abstract

6‐Polyhydroxyalkylpteridines are synthesised by oxidation of the corresponding pyrano[3,2‐g]pteridines, the latter ones having been obtained by condensation between 5,6‐diaminopyrimidines 1a,b and phenylhydra‐zones 2a‐e. The relative configuration at the chiral centers of the pyrano[3,2‐g]pteridines has been determined by nmr study and X‐ray analysis. The anti‐AIDS activity of several of these compounds has been tested.