Synthesis and Biological Studies of N-Alkylated Cyclic Diamines

✍ Scribed by Xiao-Qin Xiong; Feng Liang; Li Yang; Xiang Zhou; Cong-Yi Zheng; Xiao-Ping Cao

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 239 KB
• Volume: 4
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200790005

✦ Synopsis

Several alkyl-substituted mesocyclic diamines were synthesized, and their interaction with DNA were studied by melting-temperature measurements and the ethidium bromide (EB)-fluorescence competitive method. The supercoiled DNA hydrolytic cleavage by 1,4-dioctyl-1,4-diazepan-6-ol (4) was supported by the evidence from free-radical quenching and T4-ligase ligation. Preliminary pharmacological tests showed that only 1,4-dioctyl-1,4-diazepan-6-ol (4) had antitumor activity against HeLa cell lines in vitro.