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Synthesis and biological screening of 4-(3,3-dimethylspiro{bicyclo[2.2.1]heptan-2,5′-isoxazoline-2}- 3′-yl)-2-aryl-2,3-dihydro-1H-1,5-benzodiazepines

✍ Scribed by Tahira Naqvi; Deepali Mahajan; Rattan Lal Sharma; Inshad Ali Khan; Kamal K. Kapoor

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 104 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.194

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✦ Synopsis

Abstract

A series of novel 4‐(3,3‐dimethylspiro{bicyclo[2.2.1]heptan‐2,5′‐isoxazoline‐2}‐3′‐yl)‐2‐phenyl‐2,3‐dihydro‐1__H__‐1,5‐benzodiazepines were synthesized. These molecules were screened in vitro for their antifungal and antibacterial activity, and none of the tested compounds showed promising antimicrobial or antifungal activity. J. Heterocyclic Chem., 2011.

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