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Synthesis and Biological Properties of Pinane-Thromboxane A2, a Selective Inhibitor of Coronary Artery Constriction, Platelet Aggregation, and Thromboxane Formation

✍ Scribed by K. C. Nicolaou, R. L. Magolda, J. Bryan Smith, D. Aharony, E. F. Smith and A. M. Lefer

Book ID
123655878
Publisher
National Academy of Sciences
Year
1979
Tongue
English
Weight
898 KB
Volume
76
Category
Article
ISSN
0027-8424

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The pharmacokinetics and pharmacologic effects of a potent, selective inhibitor of thromboxane synthetase, CV-4151 [(E)-7-phenyl-7-(3-pyridyl)-6-heptenoic acid] on prostanoid formation and platelet aggregation were studied in 42 healthy male volunteers. The drug was well tolerated. After oral admini