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Synthesis and Biological Properties of Enzyme-Resistant Analogues of Substance P

✍ Scribed by Bengt E. B. SANDBERG; Chi-Ming LEE; Michael R. HANLEY; Leslie L. IVERSEN

Book ID
115119774
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
986 KB
Volume
114
Category
Article
ISSN
1432-1327

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## SYNOPSIS 1,4-Piperazine and 4-hydroxy proline, two small cyclic polyfunctional systems with defined stereochemistry, were introduced as "molecular scaffolds." We define a "bioactive topology," which is a derived putative low-energy conformation obtained through theoretical conformational analys