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Synthesis and Biological Properties of Enkephalin-like Peptides Containing Carboranylalanine in Place of Phenylalanine

✍ Scribed by Robert Schwyzer; Kim Quang Do; Alex N. Eberle; Jean-Luc Fauchére

Publisher
John Wiley and Sons
Year
1981
Tongue
German
Weight
421 KB
Volume
64
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The syntheses of [D‐Ala^2^, Car^4^, Leu^5^]‐enkephalin, its amide, and of [D‐Ala^2^, Car^4^, Met^5^]‐enkephalin amide are described in detail. The three compounds show pronounced morphine‐like potencies in certain bio‐assays, and were used to investigate the influence of electronic, steric and hydrophobic properties of the side‐chains of amino acids no. 4 and 5 on opioid activity (see [13]).

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