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Synthesis and biological properties of 3-methyl-10-propargyl-5,8-dideazafolic acid

โœ Scribed by Terence R. Jones; Richard F. Betteridge; David R. Newell; Ann L. Jackman


Book ID
112129403
Publisher
Journal of Heterocyclic Chemistry
Year
1989
Tongue
English
Weight
550 KB
Volume
26
Category
Article
ISSN
0022-152X

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis and biological evaluation of 9
โœ Mark Wall; Stephen J. Benkovic ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 35 KB

## Abstract The folate analogue, 9โ€thiaโ€5,10โ€dideazafolic acid (**3b**), was obtained in an efficient twoโ€step procedure in an overall yield of 60%. The previously unknown intermediate dimethylโ€thiocarbamic acid Sโ€(2โ€aminoโ€3,4โ€dihydoโ€4โ€oxoโ€pyrido[2,3โ€__d__]pyrimidinโ€6โ€yl) ester (**5**) was prepared