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Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H37RV

โœ Scribed by Kuldeep K. Roy; Supriya Singh; Sandeep K. Sharma; Ranjana Srivastava; Vinita Chaturvedi; Anil K. Saxena


Book ID
113495896
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
485 KB
Volume
21
Category
Article
ISSN
0960-894X

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Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I