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Synthesis and Biological Evaluation of Pyrimidine-Based Dual Inhibitors of Human Epidermal Growth Factor Receptor 1 (HER-1) and HER-2 Tyrosine Kinases

โœ Scribed by Cha, Mi Young; Lee, Kwang-Ok; Kang, Seok-Jong; Jung, Young Hee; Song, Ji Yeon; Choi, Kyung Jin; Byun, Joo Yun; Lee, Han-Jae; Lee, Gwan Sun; Park, Seung Bum


Book ID
115485332
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
410 KB
Volume
55
Category
Article
ISSN
0022-2623

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โœ Marianna Zavodovskaya; Michael J. Campbell; Betty A. Maddux; Laura Shiry; Geoffr ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 268 KB ๐Ÿ‘ 2 views

## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFโ€1 receptor (IGFโ€1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFโ€7 cells engineered to o