Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT

Synthesis and Biological Evaluation of N

Synthesis and Biological Evaluation of Novel Analogues and Prodrugs of the Cytotoxic Antibiotic CC-1065 for Selective Cancer Therapy

✍ Lutz F. Tietze; Tobias Herzig; Tim Feuerstein; Ingrid Schuberth 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB 👁 1 views

This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI analogues 8a and 8b were synthesized by alky