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Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents

โœ Scribed by Yang, Jee Sun; Park, Chun-Ho; Lee, Chulho; Kim, Hwan; Oh, Changmok; Choi, Yejoo; Kang, Jong Soon; Yun, Jieun; Jeong, Jin-Hyun; Kim, Myung-Hwa; Han, Gyoonhee


Book ID
125832279
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
605 KB
Volume
85
Category
Article
ISSN
0223-5234

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## Abstract 2,4(1__H__,3__H__)โ€Quinazolinediones 3aโ€“c, lumazine (3d) and thieno[2,3โ€__d__]pyrimidineโ€2,4(1__H__,3__H__)โ€dione (8) were silylated and condensed with methyl 2,3โ€dideoxyโ€3โ€fluoroโ€5โ€__O__โ€(4โ€phenylbenzoyl)โ€ฮฒโ€Dโ€__erythro__โ€pentofuranoside (2) by using trimethylsilyl triflate as a catalys