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Synthesis and biological evaluation of novel tamoxifen analogues

✍ Scribed by Christodoulou, Michael S.; Fokialakis, Nikolas; Passarella, Daniele; García-Argáez, Aída Nelly; Gia, Ornella Maria; Pongratz, Ingemar; Dalla Via, Lisa; Haroutounian, Serkos A.

Book ID
120467154
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
738 KB
Volume
21
Category
Article
ISSN
0968-0896

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Original 1,4-benzoxazine analogues of ellipticine were prepared using a general synthetic route that relied on an anionic ring annulation as the key transformation. The interest of this approach lies on the possibility of an easy entrance to a wide range of derivatives from the phenol intermediate.