Synthesis and Biological Evaluation of Novel Steroidal Pyrazoles as Substrates for Bile Acid Transporters.
โ Scribed by Laxminarayan Bhat; Bernd Jandeleit; Tracy M. Dias; Tristen L. Moors; Mark A. Gallop
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 28 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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The synthesis and biological evaluation of 4-(4-(alkyl- and phenylaminocarbonyl)benzoyl)benzoic acids (4a-4d) as non-steroidal inhibitors of steroid 5 alpha-reductase are described. The compounds were tested in vitro for inhibitory activity toward rat and human 5 alpha-reductase isozymes 1 and 2 at