This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI analogues 8a and 8b were synthesized by alky
Synthesis and Biological Evaluation of Novel Cytotoxic Phospholipids for Prostate Cancer.
β Scribed by Veeresa Gududuru; Eunju Hurh; Gangadhar G. Durgam; Seoung Soo Hong; Vineet M. Sardar; Huiping Xu; James T. Dalton; Duane D. Miller
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 150 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A severe limitation in cancer therapy is the often insufficient differentiation between malign and benign tissue using known chemotherapeutics. One approach to decrease side effects is antibodyβdirected enzyme prodrug therapy (ADEPT). We have developed new glycosidic prodrugs such as (β