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Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids

✍ Scribed by Yulia B. Malysheva; Sebastien Combes; Diane Allegro; Vincent Peyrot; Paul Knochel; Andrei E. Gavryushin; Alexey Yu. Fedorov

Book ID
116318511
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
416 KB
Volume
20
Category
Article
ISSN
0968-0896

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Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest