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Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor

✍ Scribed by Gilfillan, Lynne ;Blair, Adele ;Morris, Brian J. ;Pratt, Judith A. ;Schweiger, Lutz ;Pimlott, Sally ;Sutherland, Andrew


Book ID
120501807
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
296 KB
Volume
4
Category
Article
ISSN
2040-2503

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Reactions of 2,3-dihydro-1H-1,5-benzodia
✍ Jiaxi Xu; Gang Zuo; Wing Lai Chan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

## Abstract 2a,4‐Disubstituted 5‐benzoyl‐2‐chloro/2,2‐dichloro‐2a,3,4,5‐tetrahydro‐azeto [1,2‐a] [1,5]benzodiazepin‐1 (2H)‐ones (**3a–h**) were synthesized by cycloaddition reactions of 2,4‐disubstituted 1‐benzoyl‐2,3‐dihydr o‐1__H__‐1,5‐benzodiazepines (**2a–h**) and ketenes, generated from chloro