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Synthesis and Biological Evaluation of Nonclassical 2,4-Diamino-5-methylpyrido[2,3- d ]pyrimidines with Novel Side Chain Substituents as Potential Inhibitors of Dihydrofolate Reductases 1

โœ Scribed by Gangjee, Aleem; Vasudevan, Anil; Queener, Sherry F.


Book ID
121862289
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
204 KB
Volume
40
Category
Article
ISSN
0022-2623

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Design, synthesis and biological evaluat
โœ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan