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Synthesis and biological evaluation of new diisocyanide- and triisocyanide-99mTc complexes

✍ Scribed by N. Chemin; A. Du Moulinet D'Hardemare; S. Bouquillon; D. Fagret; M. Vidal

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
567 KB
Volume
47
Category
Article
ISSN
0969-8043

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✦ Synopsis

This paper describes the synthesis of four new polyisocyanides (three diisocyanides and one triisocyanide). The complexation of 99mTc with these ligands is also studied through chromatography and revealed the formation of hexacoordinated 99mTc+1 complexes. Finally, biodistributions of these complexes in mice are given and compared. Heart captations are lower than the ones with [99mTc(MIBI)6]+ but remain constant and a satisfactory lungs clearance, probably due to the metabolization of the ligands, is observed.

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