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Synthesis and biological evaluation of new benzo[f]furo[2,3-h]-and benzo[f]pyrano[2,3-h]coumarin derivatives.

✍ Scribed by Maria Tsoukka; Konstantinos E. Litinas; Demetrios N. Nicolaides; Dimitra J. Hadjipavlou-Litina

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
375 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Furocoumarins 3,5 and pyranocoumarin 7 were synthesized from the reaction of furonaphthalenediones 2,4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3‐6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3,5,7 and their precursors were tested as anti‐inflammatory/antioxidant agents. They were found to compete significantly high DMSO for OH radicals, to scavenge O~2~^−^ and to inhibit lipoxygenase to a high extent.

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