Synthesis and biological evaluation of new 3,4-dihydro-6-methyl-5-N-methyl-carbamoyl-4-(substituted phenyl)-2(1H)pyrimidinones and pyrimidinethiones
✍ Scribed by YS Sadanandam; MM Shetty; PV Diwan
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 383 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0223-5234
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A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact