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Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: A search for novel cyclooxygenase and lipoxygenase inhibitors

✍ Scribed by Morshed A. Chowdhury; Zhangjian Huang; Khaled R.A. Abdellatif; Ying Dong; Gang Yu; Carlos A. Velázquez; Edward E. Knaus

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
401 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

Lipoxygenase pharmacophore Cyclooxygenase and 5-lipoxygenase inhibition Anti-inflammatory activity

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Synthesis of new 1-(2-, 3-, or 4-methane
Synthesis of new 1-(2-, 3-, or 4-methanesulfonylphenyl)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors
✍ Morshed A. Chowdhury; Hua Chen; Khaled R. A. Abdellatif; Ying Dong; Kenneth C. P 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 84 KB

## Abstract magnified image A group of acetylene regioisomers were designed such that a cyclooxygenase‐2 (COX‐2) SO~2~Me pharmacophore was located at the ortho‐, meta‐, or para‐position of the acetylene C‐1 phenyl ring, and an iron‐chelating 5‐lipoxygenase (5‐LOX) __N__‐hydroxypyridin‐2(1__H__)‐on