Synthesis and Biological Evaluation of Highly Active Nonpeptidic α- vs. β-3 Integrin Antagonists
✍ Scribed by Georgette Thumshirn; Gabor A. G. Sulyok; Dirk Weber; Simon L. Goodman; Matthias Wiesner; Horst Kessler
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 62 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and
The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and