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Synthesis and Biological Evaluation of Halo-neplanocin A as Novel Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase

✍ Scribed by Lak Shin Jeong; Hyung Ryong Moon; Jae Gyu Park; Dae Hong Shin; Won Jun Choi; Kang Man Lee; Hea Ok Kim; Moon Woo Chun; Hee-Doo Kim; Joong Hyup Kim


Publisher
John Wiley and Sons
Year
2004
Weight
72 KB
Volume
35
Category
Article
ISSN
0931-7597

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Dedicated to Professor Dieter Seebach on the occasion of his 65th birthday Two orthogonally protected SAA building blocks were used in the synthesis of eight novel analogues of the CaaX motif present in the natural substrates of protein:geranylgeranyltransferase I (PGGT I), an enzyme involved in the