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Synthesis and biological evaluation of fully synthetic bryostatin analogues

✍ Scribed by Paul A. Wender; Jef De Brabander; Patrick G. Harran; Kevin W. Hinkle; Blaise Lippa; George R. Pettit

Book ID
104260162
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
227 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The ~ first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macmtransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin I and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

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ChemInform Abstract: Synthesis and Biolo
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