✦ LIBER ✦

Synthesis and Biological Evaluation of dl -4,4-Difluoroglutamic Acid and dl -γ,γ-Difluoromethotrexate

✍ Scribed by Tsukamoto, Takashi; Kitazume, Tomoya; McGuire, John J.; Coward, James K.

Book ID: 126402256
Publisher: American Chemical Society
Year: 1996
Tongue: English
Weight: 32 KB
Volume: 39
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm960522i

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and Biological Evaluation of d

Synthesis and Biological Evaluation of dl -4,4-Difluoroglutamic Acid and dl -γ,γ-Difluoromethotrexate

✍ Tsukamoto, Takashi; Kitazume, Tomoya; McGuire, John J.; Coward, James K. 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 231 KB

ChemInform Abstract: Facile Synthesis of

ChemInform Abstract: Facile Synthesis of DL-4,4-Difluoroornithine, DL-4,4-Difluoroglutamine, and γ-DL-4,4-Difluoroglutamyl-Containing Peptides: Regiospecific Addition of Nucleophiles to N-Cbz-di-tert-butyl-DL-4,4- difluoroglutamate.

✍ T. TSUKAMOTO; J. K. COWARD 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB

Synthesis and Biological Activity of Fol

Synthesis and Biological Activity of Folic Acid and Methotrexate Analogues Containing l - threo -(2 S, 4 S )-4-Fluoroglutamic Acid and dl -3,3-Difluoroglutamic Acid

✍ Hart, Barry P.; Haile, William H.; Licato, Nicholas J.; Bolanowska, Wanda E.; Mc 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 425 KB

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Activity of Folic Acid and Methotrexate Analogues Containing L-threo-(2S,4S)-4-Fluoroglutamic Acid and DL-3,3- Difluoroglutamic Acid.

✍ B. P. HART; W. H. HAILE; N. J. LICATO; W. E. BOLANOWSKA; J. J. MCGUIRE; J. K. CO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB

Synthesis and Biological Evaluation of N

Synthesis and Biological Evaluation of N α -(4-Amino-4-deoxy-10-methylpteroyl)- dl -4,4-difluoroornithine

✍ Tsukamoto, Takashi; Haile, William H.; McGuire, John J.; Coward, James K. 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 195 KB

Synthesis of tritium-labeled DL-γ-carbox

Synthesis of tritium-labeled DL-γ-carboxyglutamic acid and its cyclic form 5-oxo-2,4-pyrrolidine dicarboxylic acid

✍ Yoshinori Ishikawa; Roy E. Wuthier 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 407 KB

By condensing diethyl ethoxymethylenemalonate with diethyl acetamidomalonate, 5-hydroxy-2,4-dicarbethoxypyrrole was prepared. Hydrogenation over Pt-C to 5-oxo-2,4-dicarbethoxypyrrolidine, followed by alkaline hydrolysis gave y-carboxyglutamate. Mild alkaline hydrolysis yielded 5-oxo-2,4-pyrrolidine