Synthesis and pharmacological evaluation
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Ramakrishna V.S. Nirogi; Anand V. Daulatabad; G. Parandhama; Shaikh Mohammad; K.
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Article
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2010
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Elsevier Science
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English
β 410 KB
A series of novel aryl aminosulfonamides was designed and synthesized as 5-HT 6 receptor ligands. Many compounds screened in a functional reporter gene based assay displayed potent antagonistic activity with Kb values in the range of 0.02-10 nM. The lead compound 11m exemplified in this series showe