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Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins. Part 2

✍ Scribed by Combes, Sébastien; Barbier, Pascale; Douillard, Soazig; McLeer-Florin, Anne; Bourgarel-Rey, Véronique; Pierson, Jean-Thomas; Fedorov, Alexey Yu.; Finet, Jean-Pierre; Boutonnat, Jean; Peyrot, Vincent

Book ID
120029917
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
954 KB
Volume
54
Category
Article
ISSN
0022-2623

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A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.