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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. Part 10. 14-O-Methyl derivatives of 5-methylnaltrexone and 5-methylnaloxone

โœ Scribed by Helmut Schmidhammer; Christine Nussbaumer; Dinesh Patel; John R. Traynor


Publisher
John Wiley and Sons
Year
1994
Tongue
German
Weight
265 KB
Volume
77
Category
Article
ISSN
0018-019X

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## Abstract The 14โ€__O__โ€benzylnaltrexones **3**โ€“**6** were prepared from naltrexone (**2**) in several steps. The novel compounds were biologically evaluated in radioligand binding and in [^35^S]GTP__ฮณ__S functional assays in comparison to the reference compound naltrexone. In the binding assay, c