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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 21. 1 Novel 4-Alkoxy and 14-Phenylpropoxy Derivatives of the μ Opioid Receptor Antagonist Cyprodime ⊥

✍ Scribed by Spetea, Mariana; Schüllner, Falko; Moisa, Radu C.; Berzetei-Gurske, Ilona P.; Schraml, Barbara; Dörfler, Cynthia; Aceto, Mario D.; Harris, Louis S.; Coop, Andrew; Schmidhammer, Helmut


Book ID
118017116
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
90 KB
Volume
47
Category
Article
ISSN
0022-2623

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The 5-methyl and 14-ethoxy substituted analogues (compounds 2 -4) of the 6 opioid receptor antagonist naltrindole showed similar selectivity when compared with the reference drug. Compound 2 was a 6 receptor antagonist in the mouse vas deferens preparation (MVD) exhibiting considerably higher select