Synthesis and biological activity of the hexalin moiety of compactin (ML-236B)
✍ Scribed by Clayton H. Heathcock; Michael J. Taschner; Terry Rosen; James A. Thomas; Cheri R. Hadley; George Popják
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 235 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We present here the first report of a transformation system developed for the filamentous, ML-236B (compactin)-producing fungus Penicillium citrinum. Hygromycin B-resistant colonies were obtained after treatment of protoplasts with a vector containing an Escherichia coli hygromycin B phosphotransfer
## Abstract Starting from (__R__)‐__O__‐benzylglycidol and a sulfur‐stabilized allyl anion, a (3 + 3) synthesis of the α,β‐unsaturated (6__S__)‐δ‐lactone 7 is achieved. Subsequent diastereoselective addition of a phenyldimethylsilyl cuprate and unmasking of the latent hydroxy function provides the
2-adamantanole was the protecting group of the aspartate 13-COOH moiety during the peptide synthesis and survived the final peptide cleavage and deprotection carried out under controlled conditions. MEN 10586 showed an agonist activity comparable to that of the parent compound MEN 10210 at NK~ and N