✦ LIBER ✦

Synthesis and biological activity of the four stereoisomers of 6-[4-[3-[[2-hydroxy-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propyl]amino]-propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a combined vasodilator and .beta.-adrenoceptor antagonist

✍ Scribed by Howson, W.; Kitteringham, J.; Mistry, J.; Mitchell, M. B.; Novelli, R.; Slater, R. A.; Swayne, G. T. G.

Book ID: 119950114
Publisher: American Chemical Society
Year: 1988
Tongue: English
Weight: 745 KB
Volume: 31
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00397a014

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis, characterization, and biologi

Synthesis, characterization, and biological assessment of the four stereoisomers of the H3 receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3′]bipyrrolidinyl-1′-yl)phenyl]benzamide

✍ Gao, Zhongli; Hurst, William J.; Guillot, Etienne; Nagorny, Raisa; Pruniaux, Mar 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 385 KB

2-halogenoethylamines as potential folic

2-halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl-N-[1-(2-amino-4-hydroxy-6-methyl-5-pyrimidyl)-3-(2-chloro)- propyl]-p-aminobenzoate

✍ A. M. Triggle; D. J. Triggle 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB

The synthesis of three isotopomers of 2-

The synthesis of three isotopomers of 2-methyl-2-(4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl]phenoxy)propionic acid, a potent and selective peroxisome proliferator-activated receptor alpha agonist

✍ Fengjiun Kuo; Dean K. Clodfelter; Nagy A. Farid; William J. Wheeler; Lennon H. M 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB

## Abstract Although fenofibrate (**1a**) is commercially available and clinically effective in lowering serum triglycerides, its activity and sub‐type selectivity at the PPARα receptors are only moderate; therefore, there exists a need for more potent and sub‐type selective PPARα agonists. To that

Synthesis and Activity of a Metabolite o

Synthesis and Activity of a Metabolite of (S)-6-Amino-5- (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido) -3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (CX-659S).

✍ Yoshiaki Isobe; Masanori Tobe; Osamu Takahashi; Yuso Goto; Yoshifumi Inoue; Fumi 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 104 KB 👁 1 views

Discovery of N-[2-[5-[Amino(imino)methyl

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa1

✍ Phillips, Gary B.; Buckman, Brad O.; Davey, David D.; Eagen, Keith A.; Guilford, 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 178 KB

ChemInform Abstract: Discovery of N-[2-[

ChemInform Abstract: Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6- [3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl] -N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa.

✍ M. M. MORRISSEY; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views