## Abstract Two trisβalkoxycarbonyl homoarginine derivatives, BocβHar{Ο,Οβ²β[Z(2Br)]~2~}βOH and BocβHar{Ο,Οβ²β[Z(2Cl)]~2~}βOH, were prepared by guanidinylation of BocβLysβOH, and used for the synthesis of neoβendorphins and dynorphins. The results were compared with that obtained in the synthesis in
β¦ LIBER β¦
Synthesis and biological activity of opioid peptides containing nucleoamino acid residues
β Scribed by O.N. Chichenkov; N.V. Sumbatyan; A.N. Topin; G.A. Korshunova
- Book ID
- 119180048
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 151 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1043-6618
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Cyclization of dipeptidyl chloromethyl ketones gave 6-(4-aminobutyl)-3-carboxyethyl-5-methyl-2(1H)pyrazinone (3), 3-(4-aminobutyl)-6-carboxyethyl-5-methyl-2(1H)-pyrazinone (6), and 3,6-bis(4-aminobutyl)-5methyl-2(1H)-pyrazinone (15). Using above pyrazinone derivatives, three opioid mimetics were pre