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Synthesis and biological activity of oligomer-model compounds containing units of a key platelet-binding disaccharide of heparin

โœ Scribed by Shuhei Koshida; Yasuo Suda; Yasuhiro Fukui; Julie Ormsby; Michael Sobel; Shoichi Kusumoto

Book ID
104261867
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
274 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A key disaccharide unit in heparin, O-(2-deoxy-2-sulfamido-6-O-sulfo-a-D-glucopyranosyl)-(1---.4)-2-O-sulfo-Ot-L-idopyranosyluronic acid, was previously found to be responsible for the binding interaction of heparin to platelets. A clustering effect to enhance the binding was found to be dependent on the number and frequency of the disaccharide units in a heparin molecule. To systematically examine the clustering effect, three oligomermodel compounds containing two or three units of the disacchaxide were synthesized. These compounds inhibited 3H-labelled heparin binding to human platelets more strongly than a compound containing only one unit of the disaccharide.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of oligomeric assemblies of a
Synthesis of oligomeric assemblies of a platelet-binding key disaccharide in heparin and their biological activities
โœ Shuhei Koshida; Yasuo Suda; Michael Sobel; Shoichi Kusumoto ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 92 KB

Heparin, highly sulfated glycosaminoglycan, binds to platelets. A key disaccharide unit in heparin was previously found to be responsible for the binding, and the frequency of the disaccharide unit was important for the binding potency. A newly developed method based on the reductive amination was e