Adenosine receptor prodrugs: Synthesis a
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Michel C. Maillard; Olga NikodijeviΔ; Kathryn F. Lanoue; Deborah Berkich; Xiao-D
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Article
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1994
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John Wiley and Sons
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English
β 977 KB
5'-Ester derivatives of the potent adenosine agonists N6-[4-[[[[4-[[[(2-acetylaminoethyl)amino]carbonyl]methyl] anilino]carbonyl]methyl]phenyl]adenosine (N-AcADAC; 1) and N6-cyclopentyladenosine (CPA; 2) were prepared as prodrugs. Both alkyl esters or carbonates (designed to enter the brain by virtu