Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters
β Scribed by Atwal, Karnail S.; Bergey, James L.; Hedberg, Anders; Moreland, Suzanne
- Book ID
- 115311449
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 880 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
The title compound, C 13 H 15 NO 3 , contains a chiral cisdisubstituted oxazine linked to a phenyl ring at the C-2 atom. The racemic crystal structure is stabilized by both intra-and intermolecular C-HΓ Γ ΓO hydrogen bonds.
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonβ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cβbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des