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Synthesis and biological activity of methotrexate analogs with two acid groups and a hydrophobic aromatic ring in the side chain

โœ Scribed by Rosowsky, Andre; Bader, Henry; Freisheim, James H.


Book ID
125953038
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
808 KB
Volume
34
Category
Article
ISSN
0022-2623

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## Abstract (+)โ€5โ€ฒโ€Oxaโ€gloeosporone (2), an analog of the natural germination selfโ€inhibitor (โˆ’)โ€gloeosporone (1), is synthesized, largely following our previously published route to the parent compound. Thus, the hydroxybutyl side chain of 2 was introduced by hydroboration of a butenyl group (โ†’ 14