Synthesis and Biological Activity of Metabolically Stabilized Cyclopentyl Trisphosphate Analogues of D-myo-Ins(1,4,5)P3
✍ Scribed by Liuyin Zhang; Wei Huang; Akihiko Tanimura; Takao Morita; Sitaram Harihar; Daryll B. DeWald; Glenn D. Prestwich
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 305 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1860-7179
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
The synthesis of the (Y and p anomers of the title compound (1) was accomplished from o-mannose. In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosp
t\_-Quebrachitol was O-demethylated to give lt\_-chiro-inositol which, on treatment with dibutyltin oxide, benzyl chloride, and tetrabutylammonium iodide in acetonitrile, gave mainly crystalline lo-2,3,5tri-0-benzyl-chiro-inositol (Sal together with lt\_-2,3,5,6-tetra-0-benzyl-chiro-inositol. Catal