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Synthesis and Biological Activity of Conformationally Restricted Analogues of Milnacipran: (1 S ,2 R )-1-Phenyl-2-[( R )-1-amino-2-propynyl] -N,N- diethylcyclopropanecarboxamide Is a Novel Class of NMDA Receptor Channel Blocker

โœ Scribed by Shuto, Satoshi; Ono, Shizuka; Imoto, Hiroaki; Yoshii, Kiyonori; Matsuda, Akira


Book ID
125974925
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
229 KB
Volume
41
Category
Article
ISSN
0022-2623

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Conformationally restricted P1-P1' trans
โœ Michael J. Melnick; Sharon N. Bisaha; Ronald B. Gammill ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 256 KB

A concise synthesis and determination of absolute stereochemistry of two novel diastereomeric cyclopropyl containing transition state mimics isdescribed. A major advance in the development of renin inhibitors was the replacement of the scissile bond (PI-PI') with "transition state mimics" such as st