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Synthesis and biological activity of bi/tricyclic azasugars fused thiazolidin-4-one and thiazinan-4-one by microwave-assisted tandem Staudinger/aza-Wittig/cyclization

โœ Scribed by Xiaoliu Li; Zhanbin Qin; Tianyu Yang; Hongzhi Zhang; Sinan Wei; Chunxiao Li; Hua Chen; Ming Meng


Book ID
113496760
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
645 KB
Volume
22
Category
Article
ISSN
0960-894X

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Novel pseudonucleosides with benzylamino group on 5 0 -position (4) were synthesized by using the microwave-assisted one-pot tandem Staudinger/aza-Wittig/reduction reaction in good yields of 55.2-71.7%. The deacetylation of 4 afforded compounds 5. HIV-1 reverse transcriptase (RT) inhibitory and anti