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Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I

✍ Scribed by Chatterjee, Sankar; Ator, Mark A.; Bozyczko-Coyne, Donna; Josef, Kurt; Wells, Gregory; Tripathy, Rabindranath; Iqbal, Mohamed; Bihovsky, Ron; Senadhi, Shobha E.; Mallya, Satish; O'Kane, Teresa M.; McKenna, Beth Ann; Siman, Robert; Mallamo, John P.


Book ID
127045410
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
240 KB
Volume
40
Category
Article
ISSN
0022-2623

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## Abstract A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.