Synthesis and biological activity of a fluoroketonucleoside: 7-(3-deoxy-3-fluoro-β-d-glycero-hex-2-enopyranosyl-4-ulose)theophylline
✍ Scribed by Françoise Leclercq; Marie-José Egron; Kostas Antonakis; M. Idriss Bennani-Baiti; Charles Frayssinet
- Book ID
- 108309128
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 477 KB
- Volume
- 228
- Category
- Article
- ISSN
- 0008-6215
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Replacement of natural sugars by 4-deoxy-D-lyxo-hexose ("4-deoxy-D-mannose", 8) as the component parts of saccharides may endow compounds with new functions or biological activities. In previous studies, syntheses of 8 gave low overall yields or required many steps 1-4 Thus a simplified synthetic ro
## Abstract Three trisaccharide derivatives of the type β‐D‐Hex__p__‐(1 → 4)‐β‐D‐Glc__p__NAc(1 → 2)‐α‐D‐Man__p__‐(1 → O)(CH~2~)~7~CH~3~ have been synthesized, with Hex being either glucose (15), 4‐deoxy‐4‐fluorogalactose (20), or 4‐deoxygalactose (27). These trisaccharides have been designed for th
Synthesis of Protected Hexp-(1 → 4)-β-D-GlcpNAc-(1 → 2)-α-D-Manp-(1 → O)(CH2)7CH3 Sequences (Hex: β-D-Glc, 4-deoxy-4fluoro-β-D-Gal, or 4-deoxy-β-D-Gal) Using a Glc-GlcNPhth Donor, Eventually Fluorinated or Deoxygenated at the Oligosaccharide Level. -The title trisaccharide derivatives are prepared